Insights into quantifying the unmeasurable…

bemcrolf3.jpg

A big thanks to Prof. Rolf Groenwold from Utrecht for his talk on unmeasured confounding. I especially enjoyed the in-depth discussion of pros and cons of popular methods to ‘handle’ this problem.

Methods critically discussed included:

  • Two-stage sampling
  • Cross-over designs
  • Negative controls
  • Instrumental variables
  • Sensitivity analysis

Rolf’s reflection on dealing with multiple sources of bias simultaneously and quantifying the impact of measurement error also got everyone thinking.

Perhaps the highlight was the following quote Rolf shared with us from Mr. Donald Rumsfeld, clearly a scholar in articulating types of unmeasured confounding 😉

quote-there-are-known-knowns-these-are-things-we-know-that-we-know-there-are-known-unknowns-donald-rumsfeld-25-42-14.jpg

   Photo credit: azquotes.com

We hope you will join us again Oct. 4th for our next meeting on Mendelian Randomization. Sign up is already available on our ‘Calendar’ page.

Hope to see you then! -JR

 

 

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s